Posiciones
| # | Equipo | PJ | PG | PE | PP | GF | GC | DG | Pts. |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Bayern Munich | 6 | 5 | 1 | 0 | 23 | 5 | +18 | 16 |
| 2 | Bayer 04 Leverkusen | 6 | 4 | 1 | 1 | 16 | 7 | +9 | 13 |
| 3 | Wolfsburg | 6 | 4 | 1 | 1 | 8 | 5 | +3 | 13 |
| 4 | Borussia Dortmund | 6 | 4 | 0 | 2 | 17 | 12 | +5 | 12 |
| 5 | SC Freiburg | 6 | 3 | 3 | 0 | 9 | 4 | +5 | 12 |
| 6 | Mainz | 6 | 3 | 1 | 2 | 6 | 3 | +3 | 10 |
| 7 | FC Cologne | 6 | 2 | 3 | 1 | 10 | 8 | +2 | 9 |
| 8 | Union Berlin | 6 | 2 | 3 | 1 | 8 | 8 | +0 | 9 |
| 9 | TSG 1899 Hoffenheim | 6 | 2 | 2 | 2 | 11 | 8 | +3 | 8 |
| 10 | RB Leipzig | 6 | 2 | 1 | 3 | 12 | 7 | +5 | 7 |
| 11 | Borussia Mönchengladbach | 6 | 2 | 1 | 3 | 6 | 9 | -3 | 7 |
| 12 | Hertha Berlin | 6 | 2 | 0 | 4 | 7 | 18 | -11 | 6 |
| 13 | Stuttgart | 6 | 1 | 2 | 3 | 9 | 12 | -3 | 5 |
| 14 | Eintracht Frankfurt | 6 | 0 | 5 | 1 | 6 | 9 | -3 | 5 |
| 15 | Augsburg 1907 | 6 | 1 | 2 | 3 | 2 | 11 | -9 | 5 |
| 16 | Arminia Bielefeld | 6 | 0 | 4 | 2 | 3 | 6 | -3 | 4 |
| 17 | VFL Bochum | 6 | 1 | 1 | 4 | 4 | 13 | -9 | 4 |
| 18 | Greuther Fürth | 6 | 0 | 1 | 5 | 4 | 16 | -12 | 1 |
Partidos
| 26/09/2021 | ||
| SC Freiburg | 3 - 0 | Augsburg 1907 |
| VFL Bochum | 0 - 0 | Stuttgart |
| 25/09/2021 | ||
| Borussia Mönchengladbach | 1 - 0 | Borussia Dortmund |
| TSG 1899 Hoffenheim | 3 - 1 | Wolfsburg |
| Union Berlin | 1 - 0 | Arminia Bielefeld |
| Bayer 04 Leverkusen | 1 - 0 | Mainz |
| Eintracht Frankfurt | 1 - 1 | FC Cologne |
| RB Leipzig | 6 - 0 | Hertha Berlin |
| 24/09/2021 | ||
| Greuther Fürth | 1 - 3 | Bayern Munich |
| 19/09/2021 | ||
| Wolfsburg | 1 - 1 | Eintracht Frankfurt |
| Borussia Dortmund | 4 - 2 | Union Berlin |
| Stuttgart | 1 - 3 | Bayer 04 Leverkusen |
| 18/09/2021 | ||
| FC Cologne | 1 - 1 | RB Leipzig |
| Arminia Bielefeld | 0 - 0 | TSG 1899 Hoffenheim |
| Augsburg 1907 | 1 - 0 | Borussia Mönchengladbach |
| Mainz | 0 - 0 | SC Freiburg |
| Bayern Munich | 7 - 0 | VFL Bochum |
| 17/09/2021 | ||
| Hertha Berlin | 2 - 1 | Greuther Fürth |
| 01/10/2021 | ||
| FC Cologne | 15:30 | Greuther Fürth |
| 02/10/2021 | ||
| Borussia Dortmund | 10:30 | Augsburg 1907 |
| Wolfsburg | 10:30 | Borussia Mönchengladbach |
| Stuttgart | 10:30 | TSG 1899 Hoffenheim |
| Hertha Berlin | 10:30 | SC Freiburg |
| RB Leipzig | 13:30 | VFL Bochum |
| 03/10/2021 | ||
| Mainz | 10:30 | Union Berlin |
| Bayern Munich | 12:30 | Eintracht Frankfurt |
| Arminia Bielefeld | 14:30 | Bayer 04 Leverkusen |
| 15/10/2021 | ||
| TSG 1899 Hoffenheim | 15:30 | FC Cologne |
| 16/10/2021 | ||
| Borussia Dortmund | 10:30 | Mainz |
| Eintracht Frankfurt | 10:30 | Hertha Berlin |
| Union Berlin | 10:30 | Wolfsburg |
| SC Freiburg | 10:30 | RB Leipzig |
| Greuther Fürth | 10:30 | VFL Bochum |
| Borussia Mönchengladbach | 13:30 | Stuttgart |
| 17/10/2021 | ||
| Bayer 04 Leverkusen | 10:30 | Bayern Munich |
| Augsburg 1907 | 12:30 | Arminia Bielefeld |
| 22/10/2021 | ||
| Mainz | 15:30 | Augsburg 1907 |
